Farmaco prescrittomi per la psoriasi

Risposta a cura di:
Dott. GIOVANNI MENCHINI

Gentile Signor Andrea,
Il collega Le ha prescritto un farmaco anticonvulsivante ben tollerabile per l'oragnismo. Ricercando in letteratura scientifica ho trovato questo articolo che potrebbe darLe un aiuto a capire perchè le è stato prescritto.
Cordiali saluti

British Journal of Dermatology
Volume 147 Issue 1 Page 130 - July 2002
doi:10. 1046/j. 1365-2133. 2002. 04806. X

CONCISE COMMUNICATION
Topiramate in the treatment of Psoriasi s: a pilot study
R. Ryback
SummaryBackground This study was initiated following a serendipitous finding in which a patient who presented with both a mood disorder and Psoriasi s experienced significant improvement of her Psoriasi s following treatment with topiramate.
Objectives To determine the efficacy of topiramate for the treatment of Psoriasi s.
Methods Seven other patients, six of whom presented with both mood disorders and Psoriasi s and one with Psoriasi s only, were treated in an open-label fashion with topiramate. Topiramate therapy was usually initiated at 15 mg day1 and gradually titrated by 15 mg week1 to an average final dose of 56 mg day1. Patients were treated for a minimum of 4 months. Psoriasi s severity was measured using the Psoriasi s area and severity index (PASI).
Results For all patients, the mean PASI score decreased from 16·1 before treatment to 7·1. For patients exhibiting improvement, the mean PASI score decreased from 14·3 to 3·9.
Conclusions These results represent the first known report of the efficacy of topiramate in the treatment of Psoriasi s.

Dott. Giovanni Menchini
Specialista attività privata
PISA (PI)